News archive

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A new strategy to determine whether nanotherapy will be effective for a patient

Scientists from the IMC participated in the development of a strategy to find out whether the treatment with advanced forms of nanomedicine will be of significant benefit to the patient, or will remain without effect.

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Polymer-based antibody mimetics (iBodies) as immune checkpoint blocker

Scientists from IMC, together with colleagues at IOCB, have developed polymeric anti-human PD-L1 antibody mimetics (iBodies) that specifically target human hPD-L1 and block the PD-1/PD-L1 interaction in vitro with the same efficacy as monoclonal antibodies.

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The electrostatic interaction of charged macromolecules takes place differently than expected

IMC’s scientists participated in a study demonstrating the influence of ionization changes during the interactions of oppositely charged (bio)macromolecules.

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Polymer composites for eco-friendly remediation of hexavalent chromium ions from wastewater

Scientists from IMC together with colleagues from BUT developed the free-standing bacterial celulose/polypyrrole membrane for the effective adsorption/reduction of the hexavalent chromium ions from polluted water.

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Counterions affect the mass spectra of compounds with multiple permanent charges

According to a study in the journal Analytical Chemistry, representative mass spectra of compounds with multiple permanent charges require appropriate counterions.

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Fluorine MRI monitoring of modified gelatin hydrogels for regenerative medicine

Gelatin-based hydrogels with fluorine-containing polymer enable in vivo monitoring via MRI, enhancing their potential for regenerative medicine.

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Ionic liquids-catalysed CO₂ conversion: a sustainable way towards non-isocyanate polyurethanes

In this study, we described the catalytic effect of ionic liquids enabling the efficient transformation of renewable CO₂
into β-hydroxyurethanes.

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Preparation of epoxy networks accelerated by metal ionic liquids

We have investigated ionic liquids as effective catalysts for the cross-linking of epoxies enabling the fast preparation of high-performance thermosets.

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Novel polymer-peptide probes for glioblastoma visualization

Scientists from the IMC in collaboration with colleagues from IAB Grenoble have developed advanced specific peptide bearing polymer probes for fluorescence imaging of glioblastomas.

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Thermoresponsive diblock copolymers for intravitreal drug delivery

Scientists from the IMC, in collaboration with colleagues from Barinthus Biotherapeutics, dealt with structural optimization of thermoresponsive polymer carriers of intravitreally administered drugs.

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Double-porous polyaniline-based cryogels with carbon nanofibers for supercapacitors

Scientist from IMC discovered that incorporation of carbon nanofibers improves electrochemical performance of polyaniline-based aerogels, which is important for energy storage applications.

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Sandwich immunoassay with single molecule counting readout based on polymer brushes

Scientists from the IMC together with colleagues from FZU and AIT (Austria) developed a highly sensitive digital immunoassay as part of an international project.

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Iron-based compounds coordinated with phospho-polymers as biocompatible MRI probes

Scientists from the IMC CAS have developed new types of biocompatible MRI probes based on iron compounds modified with water-soluble phospho-polymers. The study was published in the journal Scientific Reports.

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Polyacrylamide-cellulose hydrogel derived carbon materials for high-performance supercapacitors

The journal ACS Applied Energy Materials published a collaborative study on ultrahigh surface area hierarchically porous carbon materials and their potential use as high-performance supercapacitors.

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RGD-coated polymeric microbubbles enable drug delivery across the blood-brain barrier

We discovered that sonopermeation with microbubles enhances delivery across the blood-brain barrier of both nanocarriers and free drugs.

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Advanced polymeric vectors for the treatment of site-specific rheumatic musculoskeletal diseases

Researchers from ÚMCH, together with colleagues from BFU and the Institute of Rheumatology, developed polymer vectors with optimized drug activation for the treatment of rheumatic diseases.

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Effect of Polymer Concentration on the Morphology of the PHPMAA-g-PLA Graft Copolymer Nanoparticles Produced by Microfluidics Nanoprecipitation

Researchers from IMC have demonstrated the feasibility of preparing PHPMAA-g-PLA polymer nanoparticles with various morphologies using microfluidic channels.

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Polymeric adjuvants designed to increase the efficiency of polymer nanosystems in tumor therapy

We have developed a polymer nanosystem that can increase the uptake of other therapeutic nanosystems in tumor tissue, thereby significantly increasing their therapeutic efficacy.

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Nano-FTIR spectroscopy of surface confluent polydopamine films

Nanoscale infrared characterization of polydopamine layers was published in Colloids and Surfaces B: Biointerfaces.

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Electrodestruction of bacterial biofilm on polymer layers

Scientists from the IMC have developed polymer layers capable of significantly increasing the efficiency of electrosterilization of surfaces with bacterial biofilm.