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A new method of nanoparticle surface modification for diagnostic applications
Team Polymer and Colloidal Immunotherapeutics developed an efficient method for anchoring synthetic polymers to the surface of magnetic nanoparticles. The effectiveness of this surface treatment was subsequently assessed in vivo in collaboration with CAPI team from the 1st Faculty of Medicine.
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Homogeneous ion-exchange membranes for hydrogen production by alkaline water electrolysis
In the framework of the European project NEWELY, the scientific team of IMC and UCT has developed homogeneous ion-exchange membranes with low surface resistance for highly efficient membrane-based alkaline electrolysis of water. The project was awarded the "Best Innovation Award 2022“ of the Clean Hydrogen Partnership at the European Hydrogen Week 2022 - "The secret to success is in the membrane".
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Anti-cancer micellar delivery system with ultrasound-triggered release of the active ingredient
A Czech-French research team has developed an anti-tumor micellar drug delivery system with ultrasound-triggered drug release and successfully tested it in a mousebrain tumor - glioma model. The biodistribution of the system within the organism and its accumulation in tumor can be monitored in real time as a direct feedback by PET or fluorescence.
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Polymer Nanoprobes for Fluorescence-Guided Surgery of Malignant Head-and-Neck Tumors and Metastases
Scientists from the IMC prepared fluorescent polymer probes designed for fluorescent guided surgery, which can light up tumors and more accurately showed tumor borders for easier resection of the whole tumor.
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Polypyrrole Aerogels: Efficient Adsorbents of Cr(VI) Ions from Aqueous Solutions
Scientist from the IMC developed a novel polypyrrole-based adsorbent of Cr(VI) ions with good handling properties for water purifications.
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Influence of coating of upconverting nanoparticles on their degradation and cytotoxicity
IMC scientists designed two-color optical contrast agent with reduced degradability under physiological conditions that is suitable for in vitro and in vivo imaging.
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Study of changes in illumination intensity in the kinetics of the singlet oxygen
As part of the Czech-German-Japanese collaboration, scientists from the IMC participated in the study of changes in illumination intensity in the kinetics of the singlet oxygen signal and photosensitizer phosphorescence in vivo, using time-resolved optical detection in the NIR.
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Hybrid Layers of Donor-Acceptor Copolymers with Silver Nanoparticles
In the journal Nanomaterials, an article revealing the influence of electron-donor units on the formation of silver nanoparticles on the surface of thin layers of donor-acceptor copolymers was published.
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Martin Hrubý was appointed professor
He received the title of professor on the proposal of the Scientific Council of Charles University for the field of macromolecular chemistry.
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Eva Randárová received the Otto Wichterle Award
The OW Prize is awarded to selected, exceptionally high-quality young researchers of the CAS under the age of 35.
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Copolymerization modeling for the development of multifunctional copolymers
Within an international collaboration, IMC scientists participated in a study on the modeling of acrylic acid, methyl acrylate, and t-butylacrylamide copolymerization with the aim to optimize the industrial synthesis of multifunctional copolymers used in personal care products.
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Role of Membrane Features on the Permeability Behavior of Polymersomes
Within the international cooperation of IMC-UFABC, a paper focused on the influence of the permeability of polymersomes membranes on the release of encapsulated drug was published in Biomacromolecules.
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pH-responsive micelles and polymersomes obtained by microwave-assisted RAFT-PISA method
In ACS OMEGA, IMC researches presented a versatile platform for the synthesis of pH-responsive diblock copolymer (PHPMA-b-PDPA) micelles and vesicles (polymersomes) obtained via microwave-assisted RAFT-PISA which may attract considerable attention in the drug-delivery field.
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Polyaniline/metal-organic framework composites: Effect of framework functionalization
Journal ACS Applied Materials & Interfaces published a paper about influence of Zr-based metal-organic framework structure on properties of its composites with polyaniline.
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Conductive mechanisms in cement/CNT composites explored for future geopolymer studies.
First step of future investigations on dielectric properties of geopolymer for sensing applications in the field of building materials - international collaboration results were published in Materials and Structures.
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Multi-layered nanofibrous mats for local delivery of anticancer agent topotecan
The journal Pharmaceutics published a paper on nanofibrous drug carriers with prolonged release and biological activity against cancer cells with potential for local treatment of e.g. intraocular tumor retinoblastoma.
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Rose Bengal-conjugated hexagonal upconverting nanoparticles producing reactive singlet oxygen
IMC scientists designed new Rose Bengal-conjugated and PEG-coated hexagonal upconverting nanoparticles to kill tumor cells by photodynamic therapy.
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In vivo Post-Grafting Safety of Reprogrammed Human iPSC-Derived Neuronal Precursors
The journal Cell Transplantation has published results of in-vivo study of the survival, differentiation, and safety/tumorigenicity of reprogrammed human induced pluripotent stem cells-derived neuronal precursors for treatment of neurodegenerative diseases.
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Poly(glycidyl methacrylate)-based polymers for automotive coatings
In research sponsored by the U.S. company Axalta Coating Systems, IMC scientists described the synthesis of well-defined low-molecular weight (co)polymers of glycidyl methacrylate applicable in the formulation of automotive coating mixtures.
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Newly developed gel polymer electrolytes based on crosslinked poly (2-oxazolines)
Journal Solid State Ionics published work on the development of electrochemically, mechanically and thermally stable, efficient and versatile “green” gel polymer electrolytes for lithium-ion batteries based on cross-linked 2-polyoxazolines.
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