Layer-by-layer assembly of polyelectrolyte films: Effects of substitution degree on film build-up

Monika Matiyani
Lecture of the lecture cycle
24.10.2024 10:00, Lecture room A

The layer-by-layer (LbL) assembly of multilayer films through the sequential adsorption of oppositely charged polyelectrolytes enables the construction of ultrathin films at the nanoscale with a well-defined structure and specific functionalities. In recent years, there has been growing interest in the development of biocompatible coatings based on LbL films for applications in the fields of tissue engineering and implantable biomaterials. Consequently, there is a demand for an in-depth understanding of the fundamental physical and chemical characteristics of LbL films, as they have emerged as key factors in controlling film nanostructure with regard to biological processes. In this study, we present the fabrication of LbL films composed of quaternized dextran (QDex) with varying degrees of substitution and heparin (Hep) under physiological conditions. We investigated the influence of the intrinsic properties of polyelectrolytes, as well as assembly conditions, on the formation, growth, and stability of LbL films. This work provides valuable insights into the precise control of film growth and stability, which are essential for potential applications in tissue engineering and biomaterials.

The lecture is presented in English