Mgr. Martin Hrubý, Ph.D., DSc

Benchmarks for the last 10 years

Selected publications

• Urbánek, T., Ivanko, I., Svoboda, J., Tomšík, E., Hrubý, M. Selective potentiometric detection of reactive oxygen species (ROS) in biologically relevant concentrations by a modified metalized polyporphyrine sensing layer coated with nonbiofouling poly(2-alkyl-2oxazoline)s. Sensors and Actuators B - Chemical 2022, 363(15 July), 131827. IF 8.400.
• Kolouchova K., Groborz O., Cernochova Z., Skarkova A., Brabek J., Rosel D., Svec P., Starcuk Z., Slouf M., Hruby M. Thermo- and ROS Responsive Self-Assembled Polymer Nanoparticle Tracers for 19F MRI Theranostics. Biomacromolecules 2021, 22(6), 2325–2337. IF 6.092
• Švec P., Nový Z., Kučka J., Petřík M., Sedláček O., Kuchař M., Lišková B., Medvedíková M., Kolouchová K., Groborz O., Loukotová L., Konefał R. Ł., Hajdúch M., Hrubý M. Iodinated Choline Transport-Targeted Tracers. J. Med. Chem. 2020, 63(24), 15960–15978. IF 6.205
• Loukotová L, Kučka J., Rabyk M., Höcherl A., Venclíková K., Janoušková O., Páral P., Kolářová V., Heizer T., Šefc L., Štěpánek P., Hrubý M. Thermoresponsive β-glucan-based polymers for bimodal immunoradiotherapy - Are they able to promote the immune system? J. Controlled Release 2017, 268, 78-91. IF 7.877
• Havlík J., Petrakova V., Kucka J., Raabova H., Panek D., Stepan V., Zlamalova Cilova Z.,Reineck P., Stursa J., Kucera J., Hruby M., Cigler P. Extremely rapid isotropic irradiation of nanoparticles with ions generated in situ by a nuclear reaction. Nature Commun. 2018, 9, Article Number 4467. IF 11.878
• Sedlacek O., Jirak D., Galisova A., Jager E., Laaser JE., Lodge TP., Stepanek P., Hruby M. ¹⁹F Magnetic Resonance Imaging of Injectable Polymeric Implants with Multiresponsive Behavior. Chem. Mater. 2018, 30, 4892-4896. IF 10.159
• J. Trousil, O. Pavliš, P. Kubíčková, M. Škorič, V. Marešová, E. Pavlova, K. D. Knudsen, Y.-S. Dai, M. Zimmerman, V. Dartois, J.-Y. Fang, M. Hrubý. Antitubercular nanocarrier monotherapy: study of in vivo efficacy and pharmacokinetics for rifampicin. J. Controlled Release 2020, 321, 312-323. IF 7.727
• K. Kolouchova, D. Jirak, O. Groborz, O. Sedlacek, N. Ziolkowska, M. Vit, E. Sticova, A. Galisova, P. Svec, J. Trousil, M. Hajek, M. Hruby. Implant-forming polymeric ¹⁹F MRI-tracer with tunable dissolution. J. Controlled Release 327, 2020, 50-60. IF 7.727
• J. Trousil, Z. Syrová, N.-J. Knudsen Dal, D. Rak, R. Konefal, E. Pavlova, J. Matějková, D. Cmarko, P. Kubíčková, O. Pavliš, T. Urbánek, M. Sedlak, F. Fenaroli, I. Raška, P. Stepanek, M. Hruby. Rifampicin nanoformulation enhances treatment of tuberculosis in zebrafish. Biomacromolecules 2019, 20(4), 1798-1815. IF 6.092
• L. Loukotová, A. Bogomolova, R. Konefal, M. Špírková, P. Štěpánek, M. Hrubý. Hybrid κ-carrageenan-based polymers showing "schizophrenic" lower and upper critical solution temperatures and potassium responsiveness. Carbohydrate Polym. 2019, 210, 26-37. IF 7.182
• M. Vetrik, J. Mattova, H. Mackova, J. Kucka, P. Pouckova, O. Kukackova, J. Brus, S. Eigner-Henke, O. Sedlacek, L. Sefc, P. Stepanek, M. Hruby. Biopolymer strategy for the treatment of Wilson´s disease. J. Controlled Release 2018, 273, 131-138. IF 7.727

Featured research

• Thermoresponsive β-glucan-based polymers for bimodal immunoradiotherapy – Are they able to promote the immune system? (2017)
• pH-responsive poly(2-ethyl-2-oxazoline) conjugates with doxorubicin for cancer therapy: In vitro and in vivo evaluation and direct comparison to poly[N-(2-hydroxypropyl)methacrylamide] analogues (2017)
• Chelating biopolymer strategy for the treatment of Wilson's disease (2018)
• Fluorinated Ferrocene Moieties as a Platform for Redox-Responsive Polymer ¹⁹F MRI Theranostics (2022)
• pH-Dependent disruption of giant polymer vesicles: a step towards biomimetic membranes (2023)

Scientific awards

Five selected invited talks

• Hrubý, M.,Loukotová, L.,Rabyk, M.: Polysaccharide-graft-poly(2-alkyl-2-oxazoline) hybrid copolymers: versatile materials for bioapplications. POLY Graphical Abstracts. Orlando: American Chemical Society, 2019. POLY-46 ACS National Meeting & Exposition /257./. Orlando, USA, 31.3.-4.4.2019
• Hrubý, M.,Kučka, J.,Pánek, J.,Štěpánek, P. Polymer radionuclide conjugates - the selected stories from the Institute of Macromolecular Chemistry AS CR. Book of Abstracts. Paris: SETCOR Conferences & Exhibitions, 2017. p. 99 Nanotech France 2017. Paris, France, 28.-30.6.2017
• Hrubý, M.,Sedláček, O.,Kučka, J.,Vetrík, M.,Monnery B., D.,Hoogenboom, R. Effect of ionizing irradiation on biocompatible polymers Program Book. Philadelphia: American Chemical Society. 2016. POLY-232 ACS National Meeting & Exposition /252./. Philadelphia, USA, 21.-25.8.2016
• Hrubý, M.,Kučka, J.,Sedláček, O.,Vetrík, M.,Pospíšilová, A.,Švec, P.,Štěpánek, P. Polymers and supramolecular polymer systems for radionuclide delivery Book of Abstracts. Budapest : Polymer Chemistry Research Group, Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 2015,(Kasza, G.). s. 9 ISBN 978-963-12-3161-8 International Symposium on Amphiphilic Polymers, Networks, Gels and Membranes - APNGM15. Budapest, Hungary, 30.8.2015-2.9.2015
• Hrubý, M.,Filippov, S.,Pánek, J.,Kučka, J.,Sedláček, O.,Štěpánek, P. Poly(2-alkyl-2-oxazolynes) as promising radionuclide carriers for nuclear medicine Abstracts of 248th ACS National Meeting & Exposition. San Francisco : ACS, 2014. POLY-214 American Chemical Society National Meeting & Exposition /248./. San Francisco, USA, 10.-14.8.2014

Selected patents

• Hrubý, M.,Vetrík, M.,Kučka, J.,Macková, H.,Štěpánek, P.,Humajová, J.,Poučková, P.,Urbánek, P. Polysaccharide-based polymer and its use for the prevention and treatment of the Wilson's disease. CZ307064, EP3370735, WO2017076378A1 (priority 2015-11-02)
• Hrubý, M.,Brezániová, I.,Král, V. Photoactivable nanoparticles for photodynamic applications, method of their production, pharmaceutical composition thereof and its use. CZ307681, WO2017148454 (priority 2016-02-29)

Major contributions to launching the careers of outstanding researchers

I have been teaching 3 courses on the use of polymers in biomedicine for master and Ph.D. students, and also have been a supervisor or supervisor-specialist of 22 Ph.D. students (16 already had successfully defended) and of Master and Bachelor degree students. Number of my Ph.D. students successfully found after defense of their theses postdocs at esteemed universities [Gent University (Belgium), University of California at Berkeley (U.S.A.), Stanford University (U.S.A.), National Institute for Materials Science – NIMS (Japan), Chang Gung University Of Science and Technology (Taiwan)]. Since my Master studies, I successfully organize a series of high school competitions and popularization courses in chemistry (e.g., Chemical Olympiad, ChemQuest). My Ph.D. student Lenka Loukotová was awarded the Sanofi Award for the best Ph.D. thesis in the field of pharmacy and biomedicine (2019).