| Description |
In the surgical removal of tumors, especially in the endoscopic removal of head and neck tumors, the surgeon's ability to recognize tumor boundaries plays a major role in removing the tumor tissue completely without the risk of removing healthy tissue. The dissertation will focus on the development of a new imaging method useful for endoscopic fluorescence-guided tumor surgery, using tailored-made polymer probes. The disertation will be based on polymeric probes directed to the tumor vasculature with activation of the imaging signal in the place of the tumor tissue. The new method should unambiguously highlight borders of solid tumors for surgeons, thus enabling the precise surgery. In order to increase the accumulation of carriers at the border of the tumor tissue, targeting groups will be used. Fluorescence probes in the near infrared area will be used to allow sufficient imaging signal even from the deep localized tissues. The dissertation will focus on the design of structures, synthesis and study of physicochemical and biological properties of polymer probes with activatable signal in the targeted part of the organism. The knowledge and experience of an applicant in organic and / or macromolecular chemistry is an advantage, along with the desire to learn new things in other disciplines such as biochemistry. The work involves close cooperation with the cooperating biological workplaces in the Czech Republic and abroad, including an internship abroad at a selected workplace. |
