| Description |
Biodegradable polymer systems show numerous applications in both human and veterinary medicine. We have recently developed and patented multiphase polymer systems based on thermoplasticized starch (TPS), polycaprolactone (PCL), and antibiotics (ATB). Morphology and properties of these systems can be adjusted by their composition and processing conditions. The basic TPS/PCL systems can be employed in technical applications, while the TPS/PCL/ATB systems can be used for the treatment of strong local infections such as osteomyelitis. The project comprises preparation of the above systems (by melt mixing), optimization of their phase structure (targeted modification of processing conditions), characterization of their morphology (electron microscopy), properties (macro- and micromechanical properties), and participation in biodegradability testing (for technical applications) and microbial susceptibility testing (medical applications, collaboration with Motol Hospital in Prague). |
