Topic details
| Topic | Synthesis and application of polymeric scavengers interacting with cationic amphiphilic peptides by charge compensation. |
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| Supervisor | Zulfiya Černochová, PhD |
| Consultant | Mgr Mariia Rabyk, PhD |
| Department | Supramolecular Polymer Systems |
| Description | Biocompatible polymer ions have been intensively studied as promising materials in the therapeutical and diagnostical fields of nanomedicine. Recently, it was demonstrated that polyanions with a high charge density are able to suppress the biological effects of the cationic amphiphilic peptide (CAMP) melittin from bee venom by binding it to the polyplex complex. In the future bio-inspirited nanostructures loaded by toxic drug inside release the drug in the needed place. Drug will be honey bee poison melittin. Needed place will be cancer. The cathelicidin is an element of innate immunity, that plays an important role in the development of the pathogenic process in psoriasis. Both cathelicidin and defensins are CAMPs are expected to behave similar to mellitin from the point of view of interaction with polyanions such as polyacrylic acid. Thus, scavenging these peptides by locally administered polyanions should break the cytokine storm cycle, leading to the induction of psoriasis, and thus suppress it. The series of nanogels acids will be prepared using microemulsion polymerization technique. In vitro testing (hemolysis on mouse erythrocytes) of obtained materials will be performed. Chemical, physical and biomedical investigation will be performed. |
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