Institute of Macromolecular Chemistry
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Topic Synthesis and Application of Silica-Coated Quantum Dots in Bioengineering
Supervisor Zulfiya Černochová, PhD
Consultant Eng Krzysztof Tadyszak, PhD
Department Supramolecular Polymer Systems
Description Quantum dots (QDs) are semiconductor nanoparticles with outstanding optoelectronic properties. More specifically, QDs are highly bright and exhibit wide absorption spectra, narrow light bands, and excellent photovoltaic stability, which make them useful in bioscience and medicine, particularly for sensing, optical imaging, cell separation, and diagnosis. In general, QDs are stabilized using a hydrophobic ligand during synthesis, and thus their hydrophobic surfaces must undergo hydrophilic modification if the QDs are to be used in bioapplications. Silica-coating is one of the most effective methods for overcoming the disadvantages of QDs, owing to silica’s physicochemical stability, nontoxicity, and excellent bioavailability. Micro and nano-particles of SiO2 will be covered by polydopamine, or by mixture of citric acid and urea, or by melamine. The covered layer will be carbonized in the presence of conducting metal ionically connected to the covered layer. The entire SiO2 can be dissolved. Rest hollow charged particles will be examined by electrochemical, fluorescent methods and other techniques needed for characterization of quantum dots.
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