Topic details
| Topic | Actively targeted polymer cancerostatics |
|---|---|
| Supervisor | Michal Pechar, PhD |
| Consultant | MS Robert Pola, PhD |
| Department | Polymer and colloid immunotherapeutics |
| Description | We will synthesize and characterize high-molecular-weight polymer carriers of therapeutics and diagnostics with enhanced accumulation in tumor tissue due to the so called enhanced permeability and retention (EPR) effect or due to the active targeting using recombinant protein ligands. We will prepare copolymers based on N-(2-hydroxypropyl)methacrylamide including those containing in their structure bonds cleavable in human organism by various mechanisms. We will study various methods of covalent and non-covalent attachment of the targeting ligands to the polymer carriers; we will evaluate the structure-activity relationship of the synthesized polymer therapeutics and diagnostics. We will also investigate the effect of various cancerostatics on the antitumor activity of both targeted and non-targeted polymer conjugates. |
| Universities |
