RNDr. Tomáš Etrych, PhD., DSc.

Selected scientific results

Publications

• B. Tomalova, M. Šírová, P. Rossmann, R. Pola, J. Strohalm, P. Chytil, V. Černý, J. Tomala, M. Kabešová, B. Říhová, K. Ulbrich, T. Etrych, M. Kovář, The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia, Journal of Controlled Release 223 (2016) 1 - 10 IF: 7,44 (15)
• E. Koziolová,O. Janoušková, L. Cuchalová, Z. Hvězdová, J. Hraběta, T. Eckschlager, L. Sivák, K. Ulbrich, T. Etrych, V. Šubr, Overcoming Multidrug Resistance in Dox-resistant Neuroblastoma Cell Lines via Treatment with HPMA Copolymer Conjugates Containing Anthracyclines and P-gp Inhibitors, Journal of Controlled Release 233 (2016) 136-146  IF:7.44 (15)
• A. Braunová, L. Kostka, S. Filippov, R. Laga, P. Černoch, M. Pechar, L. Cuchalová, Z. Hvězdová, L. Sivák, O. Janoušková, M. Šírová, T. Etrych, Tumor-targeted micelle-forming block copolymers for overcoming of multidrug resistance, Journal of Controlled Release 245 (2017) 41–51 IF:7.786 (16)
• E. Koziolová, S. Goel, P. Chytil, O. Janoušková, T. E. Barnhart, W. Cai, T. Etrych, A tumor-targeted polymer theranostics platform for positron emission tomography and fluorescence imaging, Nanoscale 9 (2017) 10906–10918, IF: 7,367 (16)
• M. Studenovský, L. Sivák, O. Sedláček, R. Konefal, V. Horkova, T. Etrych, M. Kovář, B, Říhová, M. Šírová, Polymer nitric oxide donors potentiate the treatment of experimental solid tumours by increasing drug accumulation in the tumour tissue, Journal of Controlled Release 269 (2018) 214–224 IF:7.786 (16)
• E. Koziolová, L. Kostka, L. Kotrchová, V. Šubr, R. Konefal, B. Nottelet, T. Etrych, HPMA-based linear, diblock and star-like polymer drug carriers: advanced process for their simple production, Biomacromolecules 19 (2018) 4003–4013 IF(17): 5.246
• T. Etrych, L. Daumová, E. Pokorná, D. Tušková, O. Lidický, V. Kolářová, J. Pankrác, L. Šefc, P. Chytil, P. Klener, Effective doxorubicin-based nano-therapeutics for simultaneous malignant lymphoma treatment and lymphoma growth imaging, Journal of Controlled Release 289 (2018) 44–55 IF:7.786 (16)
• R. Pola, V. Král, S. Filippov, L. Kaberov, T. Etrych, I. Sieglová, J. Sedláček, M. Fábry, M. Pechar, Polymer cancerostatics targeted by recombinant antibody fragments to GD2-positive tumor cells, Biomacromolecules 20 (2019) 412–421. IF(18): 5.667
• L. Kostka, L. Kotrchová, V. Šubr, A. Libánská, C. Ferreira, I. Malátová, H.J. Lee, T. Barnhart, J. Engle, W. Cai, M. Šírová, T. Etrych, HPMA-based Star Polymer Biomaterials with Tuneable Structure and Biodegradability Tailored for Advanced Drug Delivery to Solid Tumours, Biomaterials 235 (2020) 119728 IF: 10.31
• Bláhová M., Randárová E., Konefał R., Nottelet B., Etrych T., Graft Copolymers with Tunable Amphiphilicity Tailored for Efficient Dual Drug Delivery via Encapsulation and pH-sensitive Drug Conjugation, Polymer chemistry 11 (2020) 4438–4453  IF (20): 5.58
• Lidický O., Klener K., Machová D., Vočková P., Pokorná E., Helman K., Mavis C., Janoušková O., Etrych T., Overcoming resistance to rituximab in relapsed non-Hodgkin lymphomas by antibody-polymer drug conjugates actively targeted by anti-CD38 daratumumab, Journal of Controlled Release 328 (2020) 160–170   IF (20): 9,77
• Pola R., Pokorná E., Vočková P., Böhmová E., Pechar M., Karolová J., Pankrác J., Šefc L., Helman K., Trněný M., Etrych T., Klener P., Cytarabine nanotherapeutics with increased stability and enhanced lymphoma uptake for tailored highly effective therapy of mantle cell lymphoma, Acta Biomaterialia 119 (2021), 349–359   IF (20) = 8,95
• Appiah E., Nakamura H., Pola R., Grossmanová E., Lidický O., Kuniyasu A., Etrych T., Haratake M., Acid-responsive HPMA copolymer-bradykinin conjugate enhances tumor-targeted delivery of nanomedicine, Journal of Controlled Release 337 (2021) 546–556   IF 9,78

Patents and patent aplications

• CZ 302830 B6 (2011), EP2512521 (2014), Japan 5781084 (2015), USA  9173949 B2 (2015)
  Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs especially for treatment of solid tumours
  T. Etrych, P. Chytil, J. Strohalm, K. Ulbrich, B. Říhová
• CZ 308419 (2020)
  Block copolymer for overcoming the drug resistance of tumors to chemotherapy, its polymer conjugate with a drug, the pharmaceutical composition containing it, the method of their preparation and their use
  Tomáš Etrych, Alena Braunová, Libor Kostka, Lucie Cuchalová, Milada Šírová
• PV 2019-778
  Copolymer with hydrolytic release of anticancer cytarabine, method of its preparation and its use.
  Tomáš Etrych, Robert Pola, Michal Pechar, Pavel Klener
• PV 2019-649
  Process for the preparation of polymeric carriers for pH-controlled release of drugs and their conjugates with drugs
  P. Chytil, E. Randárová, T. Etrych
• PV 2019-627
  Fluorescent polymer, fluorescent probe and conjugation kit for advanced functional analysis of cells in hematology, immunology and microbiology, method of their preparation and their use
  T. Etrych, O. Hovorka, T. Kalina
• PV 2019-572
  Glycopolymer, method of its preparation and its use as a medicine
  P. Chytil, M. Filipová, O. Janoušková, T. Etrych, P. Bojarová, T. Vašíček
• PV 2021-423
  Fluorescently labeled polymer for tumor visualization, method of its preparation and its use
  T. Etrych, R. Pola, E. Bohmová, M. Pechar, D. Horák